Department of Experimental Biomedicine University Hospital Wuerzburg

PUBLIKATIONEN

| 2021

Scheller I, Beck S, Göb V, Gross C, Neagoe RAI, Aurbach K, Bender M, Stegner D, Nagy Z, Nieswandt B.
Thymosin beta4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets.

Haematologica. 2021 Aug 5. doi: 10.3324/haematol.2021.278537. 

Italiano JE, Bender M, Merrill-Skoloff G, Ghevaert C, Nieswandt B, Flaumenhaft R.

Microvesicles, but not platelets, bud off from mouse bone marrow megakaryocytes.

Blood. 2021 Nov 18;138(20):1998-2001. doi: 10.1182/blood.2021012496.

Bender M, Palankar R.

Hamostaseologie. 2021 Feb;41(1):14-21. doi: 10.1055/a-1325-0993. 

Cullmann K, Jahn M, Spindler M, Schenk F, Manukjan G, Mucci A, Steinemann D, Boller K, Schulze H, Bender M, Moritz T, Modlich U.

Forming megakaryocytes from murine-induced pluripotent stem cells by the inducible overexpression of supporting factors.
Res Pract Thromb Haemost. 2020 Dec 3;5(1):111-124. doi: 10.1002/rth2.12453. eCollection 2021 Jan.

| 2020

Leo Nicolai, Karin Schiefelbein, Silvia Lipsky, Alexander Leunig, Marie Hoffknecht, Kami Pekayvaz, Ben Raude, Charlotte Marx, Andreas Ehrlich, Joachim Pircher, Zhe Zhang, Inas Saleh, Anna-Kristina Marel, Achim Löf, Tobias Petzold, Michael Lorenz, Konstantin Stark, Robert Pick, Gerhild Rosenberger, Ludwig Weckbach, Bernd Uhl, Sheng Xia, Christoph Andreas Reichel, Barbara Walzog, Christian Schulz, Vanessa Zheden, Markus Bender, Rong Li, Steffen Massberg, Florian Gaertner
Vascular surveillance by haptotactic blood platelets in inflammation and infection.
Nat Commun 2020 Nov 13;11(1):5778. doi: 10.1038/s41467-020-19515-0.

Chen C, Rawat D, Samikannu B, Bender M, Preissner KT, Linn T.

Am J Transplant. 2020 Oct 25. doi: 10.1111/ajt.16375. 

Bächer C, Bender M, Gekle S.

Flow-accelerated platelet biogenesis is due to an elasto-hydrodynamic instability.
Proc Natl Acad Sci U S A. 2020 Jul 27:202002985. doi: 10.1073/pnas.2002985117. 

Ariens R, Becattini C, Bender M, Bergmeier W, Castoldi E, Devreese K, Ellis M, Gailani D, Ignjatovic V, James PD, Kerrigan S, Lambert M, Lee LH, Levi M, Maugeri N, Meijers J, Melero-Martin J, Michelson AD, Mingozzi F, Neeves K, Ni H, Olsson AK, Prohászka Z, Ranson M, Riva N, Senis Y, van Ommen CH, Vaughan DE, Weisel J.
Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress.
Res Pract Thromb Haemost. 2020 Jul 12;4(5):680-713. doi: 10.1002/rth2.12368. eCollection 2020 Jul.

Becker IC, Scheller I, Wackerbarth LM, Beck S, Heib T, Aurbach K, Manukjan G, Gross C, Spindler M, Nagy Z, Witke W, Lappalainen P, Bender M, Schulze H, Pleines I, Nieswandt B.
Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1.
Blood Adv. 2020 May 26;4(10):2124-2134. doi: 10.1182/bloodadvances.2019001303.

Bertović I, Kurelić R, Milošević I, Bender M, Krauss M, Haucke V, Jurak Begonja A.
Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes
J Thromb Haemost. 2020 Feb 13. doi: 10.1111/jth.14764. 

Green HLH, Zuidscherwoude M, Alenazy F, Smith CW, Bender M, Thomas SG.

SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics.
J Thromb Haemost. 2020 Jan 13. doi: 10.1111/jth.14735. 

| 2019

Schurr Y, Sperr A, Volz J, Beck S, Reil L, Kusch C, Eiring P, Bryson S, Sauer M, Nieswandt B, Machesky L, Bender M.
Platelet lamellipodia formation is not required for thrombus formation and stability
Blood. 2019 Dec 19;134(25):2318-2329. doi: 10.1182/blood.2019002105.

Scheller I, Stritt S, Beck S, Peng B, Pleines I, Heinze KG, Braun A, Otto O, Ahrends R, Sickmann A, Bender M, Nieswandt B.
Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets.
Haematologica. 2019 Oct 3. pii: haematol.2019.225516. doi: 10.3324/haematol.2019.225516. 

Schurr Y, Spindler M, Kurz H, Bender M.
The cytoskeletal crosslinking Protein MACF1 is dispensable for thrombus formation and hemostasis.
Sci Rep. 2019 May 22;9(1):7726. doi: 10.1038/s41598-019-44183-6.

| 2018

Aurbach K, Spindler M, Haining EJ, Bender M, Pleines I.
Blood collection, platelet isolation and measurement of platelet count and size in mice-a practical guide.
Platelets. 2018 Oct 22:1-10. doi: 10.1080/09537104.2018.1528345.

Bender M and Otto O.
No escape-a novel tool to quantify platelet intra-thrombus movements.
Thromb Haemost. 2018 Sept 118: 1515-1516.

Gekle S and Bender M.
Chapter: Red blood cell and platelet mechanics.
Book: Cardiovascular mechanics (edited by Labrosse MF)
Publisher: CRC Press, Taylor & Francis Group; 1st ed.

Spindler M, van Eeuwijk JMM, Schurr Y, Nurden P, Nieswandt B, Stegner D, Reinhold A, Bender M.
ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia.
Blood. 2018 Jun 27. pii: blood-2018-01-829259. doi: 10.1182/blood-2018-01-829259.

Pleines I, Cherpokova D, Bender M.
Rho GTPases and their downstream effectors in megakaryocyte biology.
Platelets. 2018 Jun 18:1-8. doi: 10.1080/09537104.2018.1478071.

Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra KT, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, Nieswandt B.
Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets.
Blood Adv. 2018 May 8;2(9):1040-1045. doi: 10.1182/bloodadvances.2017014001.

Gupta S, Cherpokova D, Spindler M, Morowski M, Bender M, Nieswandt B.
GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice.
Blood. 2018 Mar 8;131(10):1106-1110. doi: 10.1182/blood-2017-08-800136. 

| 2017

Stritt S, Beck S, Becker IC, Vögtle T, Hakala M, Heinze KG, Du X, Bender M, Braun A, Lappalainen P, Nieswandt B.
Twinfilin 2a is a regulator of platelet reactivity and turnover in mice.
Blood 2017, Jul 25; doi: 10.1182/blood-2017-02-770768

Bender M and Nieswandt B.
Chapter: Mouse models for platelet production and function.
Book: Molecular and cellular biology of platelet formation (edited by Schulze H and Italiano I)
Publisher: Springer; 1st ed. 2016 edition (15 Feb. 2017)

| 2016

Bender M, Stegner D, Nieswandt B.
Model systems for platelet receptor shedding.
Platelets 2016, Jun 23:1-8. 

| 2015

Alshehri OM, Hughes CE, Montague S, Watson SK, Frampton J, Bender M, Watson SP
Fibrin activates GPVI in human and mouse platelets.
Blood 2015 Sep 24;126(13):1601-8. doi: 10.1182/blood-2015-04-641654. 

Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WHA, Hoffmeister KM, Falet H.
Dynamin 2-dependent endocytosis is required for normal megakaryocyte development.
Blood 2015, Feb 5;125(6):1014-24.

Bender M, Thon JN, Ehrlicher AJ, Wu S, Mazutis L, Deschmann E, Sola-Visner M, Italiano JE Jr, Hartwig JH.
Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein.
Blood 2015, Jan 29;125(5):860-8.

Vögtle T, Cherpokova D, Bender M, Nieswandt B.
Targeting platelet receptors in thrombotic and thrombo-inflammatory disorders.
Hamostaseologie. 2015 Jan 29;35(2). 

| 2014

Cherpokova D, Bender M, Morowski M, Kraft P, Schuhmann MK, Akbar SM, Sultan CS, Hughes CE, Kleinschnitz C, Stoll G, Dragone LL, Watson SP, Tomlinson MG, Nieswandt B.
SLAP/SLAP2 prevent excessive platelet (hem)ITAM-signaling in thrombosis and ischemic stroke in mice.
Blood 2014 Oct 9. pii: blood-2014-06-580597. 

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze K, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.
Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.
Nat Commun. 2014 Sep 4;5:4746.

Bender M, Falet H.
Post-translational arginylation as a novel regulator of platelet function.
Haematologica. 2014 Mar;99(3):402-4.

| 2013

Bender M.
Dabigatran has the upper hand on warfarin.
Thromb Haemost. 2013 Jul;110(1):4.

Bender M, May F, Lorenz V, Thielmann I, Hagedorn I, Finney BA, Vögtle T, Remer K, Braun A, Bösl M, Watson SP, Nieswandt B.
Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice.
Arterioscler Thromb Vasc Biol. 2013 May;33(5):926-34.

| 2012

Duetting S, Bender M, Nieswandt B. 
Platelet GPVI: a target for antithrombotic therapy?!
Trends Pharmacol Sci. 2012; 33: 583-90. 

Hofmann S, Vögtle T, Bender M, Rose-John S, Nieswandt B.
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.
J Thromb Haemost. 2012 Oct 1. doi: 10.1111/jth.12013. 

Gupta S, Braun A, Morowski M, Premsler T, Bender M, Nagy Z, Sickmann A, Hermanns HM, Bösl M, Nieswandt B.
CLP36 is a Negative Regulator of GPVI Signaling in Platelets.
Circ Res. 2012; 111: 1410-1420.

Bender M.
High VWF, low ADAMTS13 puts women at risk.
Blood. 2012; 119:1329-30.

| 2011

Bender M, Hagedorn I, Nieswandt B. 
Genetic and antibody-induced GPVI deficiency equally protect mice from mechanically and FeCl(3) -induced thrombosis. 
J Thromb Haemost. 2011; 9: 1423-1426. 

Nieswandt B, Pleines I, Bender M. 
Platelet adhesion and activation mechanisms in arterial thrombosis and ischemic stroke. 
J Thromb Haemost. 2011; 9: Suppl 1 92-104.

| 2010

Bender M, Hofmann S, Stegner D, Chalaris A, Bosl M, Braun A, Scheller J, Rose-John S, Nieswandt B. 
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. 
Blood 2010; 116: 3347-3355.

Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B. 
ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. 
Blood 2010; 116: 1767-1775.

Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, Nieswandt B. 
Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. 
Blood 2010; 115: 3364-3373.

| 2009

May F, Hagedorn I, Pleines I, Bender M, Vogtle T, Eble J, Elvers M, Nieswandt B. 
CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. 
Blood 2009; 114: 3464-3472.

Braun A, Varga-Szabo D, Kleinschnitz C, Pleines I, Bender M, Austinat M, Bosl M, Stoll G, Nieswandt B. 
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. 
Blood 2009; 113: 2056-2063.

| 2008

Varga-Szabo D, Braun A, Kleinschnitz C, Bender M, Pleines I, Pham M, Renne T, Stoll G, Nieswandt B. 
The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. 
J Exp Med. 2008; 205: 1583-1591.

Varga-Szabo D, Authi KS, Braun A, Bender M, Ambily A, Hassock SR, Gudermann T, Dietrich A, Nieswandt B. 
Store-operated Ca(2+) entry in platelets occurs independently of transient receptor potential (TRP) C1. 
Pflugers Arch. 2008; 457: 377-387.

| 2007

Rabie T, Varga-Szabo D, Bender M, Pozgaj R, Lanza F, Saito T, Watson SP, Nieswandt B. 
Diverging signaling events control the pathway of GPVI down-regulation in vivo. 
Blood 2007; 110: 529-535.

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